Mechanisms of Sensitivity and Resistance to CDK4/6 Inhibition. Monica  Alvarez-Fernandez and Marcos Malumbres. Cancer Cell 37, April 13, 2020

Mammalian cell cycle cyclins Diego Martínez-Alonso, Marcos Malumbres. Seminars in Cell & Developmental Biology Available online 22 April 2020

Salvador-Barbero, B., Álvarez-Fernández, M., Zapatero-Solana, E., El Bakkali, A., Menéndez, M.C., López-Casas, P.P., Di Domenico, T., Xie, T., VanArsdale, T., Shields, D.J., Hidalgo, M. and Malumbres, M. (2020) CDK4/6 inhibitors impair recovery from cytotoxic chemotherapy in pancreatic adenocarcinoma. Cancer Cell, in press. [PMID: 32109375] [Full text]

Sanz-Gómez, N., de Pedro, I., Ortigosa, B., Santamaría, D., Malumbres, M., de Carcer, G. and Gandarillas, A. (2020) Squamous differentiation requires G2/mitosis slippage to avoid apoptosis. Cell Death Differ., in press. [PMID: 32080348][Full text]

Hermida, D., Mortuza, G.B., Pedersen, A.K., Pozdnyakova, I., Nguyen, T.T.T.N., Maroto, M., Williamson, M., Ebersole, T., Cazzamali, G., Rand, K., Olsen, J.V., Malumbres, M. and Montoya, G. (2020) Molecular basis of the mechanisms controlling MASTL. Mol. Cell. Proteomics 19, 326-343. [PMID: 31852836][Full text]

Hurtado B, Trakala M, Ximénez-Embún P, El Bakkali A, Partida D, Sanz-Castillo B, Álvarez-Fernández M, Maroto M, Sánchez-Martínez R, Martínez L, Muñoz J, García de Frutos P, Malumbres M. (2018) Thrombocytopenia-associated mutations in Ser/Thr kinase MASTL deregulate actin cytoskeletal dynamics in platelets. J Clin Invest. 128, 5351-5367.  [Pubmed]

de Cárcer, G., Wachowicz, P., Martínez-Martínez, S., Oller, J., Méndez-Barbero, N., Escobar, B.,  González-Loyola, A., Takaki, T., El Bakkali, A., Cámara, J.A., Jiménez-Borreguero, L.J., Bustelo, X., Cañamero, M., Mulero, F., Sevilla, M.d.l.A., Montero, M.J., Redondo, J.M. and Malumbres, M. (2017) Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis. Nat. Med. 23, 964-974.

Burgess, A., Vuong, J., Rogers, S., Malumbres, M. and O’Donoghue, S.I. (2017) SnapShot: Phosphoregulation of mitosis. Cell 169, 1358-1358e1.

Salazar-Roa, M. and Malumbres, M. (2017) Fueling the cell division cycle. Trends Cell Biol. 27, 69-81.

Hydbring, P., Malumbres, M. and Sicinski, P. (2016) Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases. Nat. Rev. Mol. Cell. Biol. 17, 280-292.

Malumbres, M. (2016) CDK4/6 inhibitors resTORe therapeutic sensitivity in HER2+ breast cancer. Cancer Cell 29, 243-244.

Doménech, E., Maestre, C., Esteban-Martínez, L., Partida, D., Pascual, R., Fernández-Miranda, G., Seco, E., Campos-Olivas, R., Pérez, M., Megias, D., Allen, K., López, M., Saha, A.K., Velasco, G., Rial, E., Méndez, R., Boya, P., Salazar-Roa, M. and Malumbres, M. (2015) AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest. Nat. Cell Biol. 17, 1304-1316.

Trakala, M., Partida, D., Salazar-Roa, M., Maroto, M., Wachowicz, P. de Cárcer, G. and Malumbres, M. (2015). Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice. Blood 126, 1707-1714.

Trakala, M., Rodríguez-Acebes, S., Maroto, M., Symonds, C.E., Santamaría, D., Ortega, S., Barbacid, M., Méndez, J. and Malumbres, M. (2015) Functional reprogramming of polyploidization in megakaryocytes. Dev. Cell 32, 155-167.

Trakala, M. and Malumbres, M. (2014). Cyclin C surprises in tumor suppression. Nat. Cell Biol. 16, 1031-1033.

Rodríguez-Díez, E., Quereda, V., Bellutti, F., Prchal-Murphy, M., Partida, D., Eguren, M., Gómez de Cedrón, M., Dubus, P., Cañamero, M., Martínez, L., Sexl, V. and Malumbres, M. (2014) Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis. Blood 124, 2380-2390.

de Cárcer, G. and Malumbres, M. (2014) A centrosomal route for cancer genome instability. Nat. Cell Biol. 16, 504-506.

Eguren, M., Álvarez-Fernández, M., García, F., López-Contreras, A.J., Fujimitsu, K., Yaguchi, H., Luque-García, J.L., Fernández-Capetillo, O., Muñoz, J., Yamano, H. and Malumbres, M. (2014). A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens. Cell Reports 6, 670-683.

Eguren, M, Porlan, E., Manchado, E., García-Higuera, I., Cañamero, M., Fariñas, I. and Malumbres, M. (2013) The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat. Commun. 4, 2880.

Pérez de Castro, I., Aguirre-Portolés, C., Fernández-Miranda, G., Cañamero, M., Cowley, D.O., van Dyke, T. and Malumbres, M. (2013) Requirements for Aurora-A in tissue regeneration and tumor development in adult mammals. Cancer Res. 73, 6804-6815.

Álvarez-Fernández, M., Sánchez-Martínez, R., Sanz-Castillo, B., Gan, P.P., Sanz-Flores, M., Trakala, M., Ruiz-Torres, M., Lorca, T., Castro., A. and Malumbres, M. (2013) Greatwall is essential to prevent mitotic collapse after nuclear envelop breakdown in mammals. Proc. Natl. Acad. Sci. USA. 110, 17374-17379.